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These commonly prescribed medications may increase your risk of dementia, study finds

These commonly prescribed medications may increase your risk of dementia, study finds

, USA TODAY
Published 6:06 p.m. ET June 24, 2019 | Updated 10:54 a.m. ET June 25, 2019

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A study showed commonly prescribed medications may be linked to a higher chance of dementia.
USA TODAY

A study out of the University of Nottingham in the United Kingdom found there is a link between dementia and certain classes of anticholinergic drugs.

The drugs — particularly antidepressants, bladder antimuscarinics, antipsychotics and antiepileptic drugs — resulted in nearly “50% increased odds of dementia,” according to the observational study published Monday in the peer-reviewed JAMA Internal Medicine journal.

Anticholinergic drugs help contract and relax muscles, according to Mayo Clinic. They can also be used to treat ulcers and prevent nausea. This is done by blocking a neurotransmitter in the brain, acetylcholine, from entering the nervous system.

Doctors prescribe these kinds of drugs to treat a variety of conditions, including chronic obstructive pulmonary disease, bladder conditions, allergies, gastrointestinal disorders and symptoms of Parkinson’s disease.

The risk is only associated with 1,095 daily doses within a 10-year period, which is equivalent to an older adult taking a strong anticholinergic medication daily for at least three years.

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“The study is important because it strengthens a growing body of evidence showing that strong anticholinergic drugs have long term associations with dementia risk,” said study author Carol Coupland, professor of medical statistics in primary care at the University of Nottingham.

“It also highlights which types of anticholinergic drugs have the strongest associations. This is important information for physicians to know when considering whether to prescribe these drugs,” she told CNN. “This is an observational study so no firm conclusions can be drawn about whether these anticholinergic drugs cause dementia.”

The study warns people against stopping any of the medications listed without consulting their doctors. 

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The researchers found no significant increases in dementia risk associated with antihistamines, skeletal muscle relaxants, gastrointestinal antispasmodics, antiarrhythmics, or antimuscarinic bronchodilators, but associations were found among other classes of anticholinergic drugs.

An estimated 47 million people worldwide were living with dementia in 2015, while in the United States around 5.7 million people have Alzheimer dementia, according to the study.

Follow Elinor Aspegren on Twitter: @elinoraspegren.

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