Milan’s entire system could change depending on whether Lucas Paqueta or Ante Rebic start tonight, while Inter might move Stefano Sensi forward.
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Marco Giampaolo’s Rossoneri are coming off two unconvincing victories against Brescia and Hellas Verona, with Davide Calabria suspended and Mattia Caldara injured.
It means Andrea Conti makes his season debut at right-back, his first start since April 28 in a 2-0 defeat to Torino.
Lucas Biglia is likely to start in midfield rather than Ismael Bennacer with Hakan Calhanoglu and Franck Kessie.
The big question is in attack, where Paqueta and Rebic are battling to join Suso and Krzysztof Piatek.
If the Brazilian is chosen, then it’ll be a 4-3-1-2 formation with him in the trequartista role, whereas Rebic would point to a 4-3-3.
Inter have a 100 per cent Serie A record under Antonio Conte, but were held to a 1-1 midweek Champions League draw by Slavia Prague.
Romelu Lukaku has shaken off a back problem, but Lautaro Martinez could be benched in favour of Matteo Politano in a 3-4-2-1 approach.
That would see on-form Sensi pushed into a more advanced role, with Nicolò Barella joining Marcelo Brozovic in midfield.
The alternative is the usual 3-5-2 with Lautaro Martinez partnering Lukaku, leaving Sensi in a more traditional deeper position.
Diego Godin returns after he was rested in the Champions League, though Antonio Candreva could make way for Danilo D’Ambrosio if he is not considered 100 per cent fit, preferred to Valentino Lazaro.
Alexis Sanchez remains on the bench as a card to be played in the second half.
Milan: G Donnarumma; Conti, Musacchio, Romagnoli, Rodriguez; Kessie, Biglia, Calhanoglu; Paqueta; Suso, Piatek
Inter: Handanovic; Godin, De Vrij, Skriniar; Candreva, Barella, Brozovic, Asamoah; Politano, Sensi; R Lukaku