Inter drop Radja Nainggolan for disciplinary reasons in this showdown with second-placed Napoli, who look to Arkadiusz Milik and a new Allan role.
It kicks off at 19.30 GMT, you can follow the build-up and action as it happens on the LIVEBLOG.
There are already eight points separating Inter in third from Napoli in second, so this Boxing Day clash is a huge fixture for the title and Champions League spots.
It can also change the title race, as Juventus were held to a 2-2 draw by Atalanta this afternoon.
The Nerazzurri were shaken this week by Nainggolan’s indiscretions, as he turned up late to training several times, so was temporarily suspended from football activity and fined €100,000.
Matteo Politano and Ivan Perisic therefore supports Mauro Icardi in a 4-3-3 formation with Borja Valero, Joao Mario and Marcelo Brozovic in midfield.
Kwadwo Asamoah returns from suspension in to the role of left-back, but Danilo D’Ambrosio is on the right rather than Sime Vrsaljko.
Napoli struggled to beat SPAL last week, winning thanks only to two desperate late saves by Alex Meret, so the young goalkeeper maintains his gloves.
Allan returns from injury and bizarrely appears to be in a right-back role, but Arkadiusz Milik gets the nod rather than Lorenzo Insigne in attack.
Napoli have lost only one of their last seven Serie A trips to Inter, winning two and drawing three. They’ve also been beaten just once in their last 11 league meetings with the Nerazzurri, home and away, with five wins and as many stalemates.
On the other hand, Inter have won their last six Serie A home games, keeping five clean sheets in a row.
Inter: Handanovic; D’Ambrosio, De Vrij, Skriniar, Asamoah; Borja Valero, Brozovic, Joao Mario; Politano, Icardi, Perisic
Inter bench: Padelli, Vrsaljko, Gagliardini, Vecino, Lautaro Martinez, Keita, Ranocchia, Dalbert, Candreva
Napoli: Meret; Allan, Albiol, Koulibaly, Mario Rui; Callejon, Fabian Ruiz, Hamsik, Zielinski; Insigne, Milik
Napoli bench: Ospina, Karnezis, Malcuit, Ghoulam, Luperto, Maksimovic, Hysaj, Rog, Diawara, Younes, Ounas, Verdi, Mertens
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