Cristiano Ronaldo, Paulo Dybala and Mario Mandzukic start for Juventus against troubled Roma, who bring back Patrik Schick and Alessandro Florenzi.
It kicks off in Turin at 19.30 GMT.
The Bianconeri have dropped points only once in Serie A this season, a 1-1 home stalemate with Genoa, and are shattering records on their way seemingly to an eighth consecutive Scudetto.
Rodrigo Bentancur returns from suspension, with Giorgio Chiellini, Medhi Benatia and Sami Khedira also available again after missing the Derby della Mole victory over Torino, but Juan Cuadrado, Joao Cancelo and Andrea Barzagli are side-lined.
It is a reunion for ex-Roma goalkeeper Wojciech Szczesny and midfielder Miralem Pjanic.
Paulo Dybala gets the nod with Cristiano Ronaldo and Mario Mandzukic, while Alex Sandro is fresh from signing a new contract.
Cristiano Ronaldo has an excellent record against Roma, contributing five goals and two assists in six Champions League meetings.
The Giallorossi go into this game with the pressure still piling on Coach Eusebio Di Francesco, as the fightback to controversially beat Genoa 3-2 only postponed his possible dismissal.
They entered the weekend in joint sixth place with Atalanta and Sassuolo, an extraordinary 22 points adrift of the leaders.
Edin Dzeko is available, but not yet fit enough to start due to a muscular issue.
Patrik Schick returns to the XI after he was dropped against Genoa, with Alessandro Florenzi, Nicolò Zaniolo and Cengiz Under in support.
Daniele De Rossi, Stephan El Shaarawy, Lorenzo Pellegrini and Ante Coric are still out of action.
Roma have lost their last seven consecutive Serie A trips to Turin, the worst run in this fixture since the 1960s.
The Giallorossi have won only one of their last seven league away games, drawing three and losing three, and the 2-0 victory at Empoli was also their lone clean sheet.
Juventus: Szczesny; De Sciglio, Bonucci, Chiellini, Alex Sandro; Bentancur, Pjanic, Matuidi; Dybala; Mandzukic, Ronaldo
Juventus bench: Pinsoglio, Perin, Benatia, Khedira, Douglas Costa, Kean, Emre Can, Rugani, Bernardeschi, Spinazzola
Roma: Olsen; Santon, Manolas, Fazio, Kolarov; Cristante, Nzonzi; Under, Zaniolo, Florenzi; Schick
Roma bench: Fuzato, Mirante, Karsdorp, Luca Pellegrini, Juan Jesus, Perotti, Dzeko, Marcano, Pastore, Kluivert
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