Diego Perotti is a late dropout for Roma against Virtus Entella, but Nicolo Zaniolo is only a substitute for the visit of his former club.
Perotti was due to captain Roma for the first time, but the winger hurt his calf during the warm-up, letting in Justin Kluivert on the left flank, while Federico Fazio is handed the armband.
Elsewhere, Rick Karsdorp and Javier Pastore are given rare chances to impress but Zaniolo is rested against Entella, where he began his professional career.
The northerners were relegated from Serie B last season but are flying high in Serie C, placing fifth in Girone A, and eliminated Genoa last time out in the Coppa Italia.
Fiorentina await tonight’s winners at the Olimpico in the quarter-finals.
Roma: Olsen; Karsdorp, Fazio, Juan Jesus, Kolarov; Cristante, Lorenzo Pellegrini; Cengiz, Pastore, Kluivert; Schick
Subs: Fuzato, Greco, Marcano, Florenzi, Kolarov, Santon, Riccardi, Zaniolo, Coric, Dzeko
Virtus Entella: Paroni; Belli, Pellizzer, Baroni, Crialese; Icardi, Paolucci, Eramo; Adorjan; Caturano, Mota Carvalho
Subs: Massolo, Benedetti, Cleur, Germoni, Bonini, De Santis, Currarino, Di Cosmo, Nizzetto, Martinho, De Rigo, Ardizzone, Petrovic, Puntoriere, Mancosu
Referee: Di Paolo
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