Leonardo Bonucci looks to be rested for Juventus, while Roma return Patrik Schick to the starting XI with Alessandro Florenzi in a more advanced role.
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The Serie A leaders welcome back Rodrigo Bentancur from suspension, with Giorgio Chiellini, Medhi Benatia and Sami Khedira also now available after injury.
Juan Cuadrado, Joao Cancelo and Andrea Barzagli remain on the treatment table.
It’s reported Bonucci will be rested for the return of Chiellini, with ex-Roma men Benatia and Wojciech Szczesny stepping in.
Miralem Pjanic completes the trio of former Giallorossi stars.
Paulo Dybala again looks likely to take the trequartista role behind Mario Mandzukic and Cristiano Ronaldo.
Roma are forced to do without Daniele De Rossi, Stephan El Shaarawy, Lorenzo Pellegrini and Ante Coric, while Edin Dzeko is probably not fit enough for a place from the start.
It means Schick is given another chance, having been dropped in favour of Nicolò Zaniolo as a False 9 in the 3-2 win over Genoa.
Zaniolo is bumped back to the position of trequartista with Cengiz Under and Florenzi, as the right-back is placed in a more advanced role.
Juventus: Szczesny; De Sciglio, Benatia, Chiellini, Alex Sandro; Bentancur, Pjanic, Matuidi; Dybala; Mandzukic, Ronaldo.
Roma: Olsen; Santon, Manolas, Fazio, Kolarov; Cristante, Nzonzi; Under, Zaniolo, Florenzi; Schick
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